The Galveston, Harrisburg and San Antonio Railway built a railway through the county from the east in 1881, and the first sale out of its Hondo City plat was made the same year.
A post office designated Hondo City began operation in 1882 and the community had 25 residents in 1884. Hondo was made the seat of Medina County in 1892.
The city was incorporated in 1942, the year Hondo Army Airfield was built on 3,675 acres of land in Hondo.
– Texas State Historical Commission, citing The History of Medina County, Texas, Railroad Transportation in Texas, and the vertical files, Dolph Briscoe Center for American History, University of Texas at Austin, Hondo, Texas; Medina County.